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the brain of otherwise healthy humans. Our findings suggest that future imaging studies should focus on more severe diseases than those addressed in this work. The results for TBI patients were generally lower as compared with the ALS subjects. The relatively small sample size and the potential for varied time lags after the injury could be the reason.

Moreover, while MRI-based delineation of the WM lesions could be readily performed using our method, the lack of structured segmentation of T~2~-hyper 50e0806aeb bladolea

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