https://devimistatinhibitor.co....m/being-homeless-alo
Koumine (KM), an alkaloid derived from Gelsemium elegans Benth., is effective against age-associated chronic diseases, but its dosage proportionality following oral administration in old individuals remains unknown. Herein, we established and validated a straightforward strategy that needs reasonable sample volumes to ascertain KM concentration in rats making use of ultra-performance liquid chromatography-tandem mass spectrometry. The most plasma focus (Cmax) of 7 mg·kg-1 KM ended up being ~12-fold and ~24-fold h
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