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RESULTS Both stain separation and normalization techniques were qualitatively and quantitively validated on a multi-tissue and multiscale dataset, with highly satisfactory results, outperforming the state-of-the-art approaches. SCAN was also tested on whole-slide images with high performances and low computational times. CONCLUSIONS The potential contribution of the proposed standardization approach is twofold the improvement of visual diagnosis in digital histopathology and the development of powerful pre-processing strategies to automate
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