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RESULTS Our outcomes revealed that SPRY4 expression was substantially increased when you look at the first-trimester cytotrophoblasts of RM patients in contrast to HCs. Additionally, SPRY4 overexpression inhibited trophoblast proliferation and accelerated apoptosis in vitro, while SPRY4 knockdown reversed these results. Mechanistically, IFN-γ -induced STAT1 phrase and activation were involved in the regulation of trophoblast proliferation and apoptosis by SPRY4, and IFN-γ promot