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ce of Hcy levels in females (SMD 0.22; 95% CI -0.16, 0.60; P=0.25) or males (SMD 0.56; 95% CI -0.13, 1.26; P=0.11) between MS patients and controls. Conclusions Higher serum levels of Hcy were noted in patients with MS when compared with control groups. And the difference was especially significant between RRMS patients and controls. Hcy may play an important role in the pathogenesis of MS. Functional studies are required to assess the effects of Hcy on patients with MS at the molecular level. © The author(s).Both the herpes zoster vi

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