https://www.selleckchem.com/pr....oducts/ngi-1ml414.ht
Hypoxia has been associated with chemoradiation resistance secondary to vascular endothelial growth factor receptor induced by hypoxia induced factor. Nitroglycerin (NTG) can reduce hypoxia induced factor-1 in tissues, and this may have antiangiogenic, proapoptotic, and anti-efflux effects. Particularly, endothelial growth factor receptor mutated (EGFRm) tumor cell lines have been shown to overexpress both vascular endothelial growth factor and HIF. In this phase 2 study, we evaluated the effect of transdermal NTG plus whole brain ra
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