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Fc-dependent resistant effector mechanisms feature complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and apoptosis. In addition, direct impacts and immunomodulatory effects donate to the effectiveness of CD38-directed antibodies. Daratumumab, the first-in-class anti-CD38 monoclonal antibody, is currently section of standard therapy regimens of both newly diagnosed along with relapsed/re

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