https://www.selleckchem.com/pr....oducts/pyrintegrin.h
Thr789Ala(C) would be expected to show 39% higher VWFAg levels; p.Thr1381Ala(C), 27% lower VWFAg levels; and p.Gln852Arg(C), 52% lower VWFRCo levels. Homozygotes for both p.Thr789Ala(C) and p.Gln852Arg(T) were predicted to show 185% higher VWFCB activity, and carriers of two copies of the p.Thr1381Ala(T)/p.Gln852Arg(T) haplotype would present a 100% increase in VWFRCo activity. These results indicate a substantial effect of common VWF variation on VWD phenotype. Although additional studies are needed to determine the true magnitude
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