https://www.selleckchem.com/pr....oducts/CGS-21680-hyd
1,2,3-Triazoles are well-established bioisosteres for amides, often installed as a result of structure-activity-relationship (SAR) exploration. A straightforward approach to assess the effect of the replacement of an amide by a triazole would start from the carboxylic acid and the amine used for the formation of a given amide and convert them into the corresponding alkyne and azide for cyclization via copper-catalyzed alkyne-azide cycloaddition (CuAAC). Herein, we report a functional-group-tolerant and operationally simp
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