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to children with ischemic stroke of known etiology and healthy controls. This study provides Class III evidence that children with cryptogenic ischemic stroke have an increased frequency of PFO compared to children with ischemic stroke of known etiology and healthy controls. PRRT2 variants have been reported in a few cases of patients with hemiplegic migraine. To clarify the role of in familial hemiplegic migraine, we studied this gene in a large cohort of affected probands. was analyzed in 860 probands with hemiplegic migraine and muta
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