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The associations between GPCRs and disease activity, disease severity, and disease phenotypes have also paved new avenues for the precise management of patients with IBD. In this review, we mainly focus on the roles of the most studied proton-sensing GPCRs, cannabinoid receptors, and estrogen-related GPCRs in the pathogenesis of IBD and their potential clinical values in IBD and some other diseases. ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.Patients with inflammatory bowel disease (IBD) are a
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