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9 mL/(min·1.73 m2) (95% CI -16.6, -9.14; P less then 0.01) decrease in glomerular filtration rate (GFR). In meta-analyses of the correlations, TMAO was strongly inversely correlated with GFR [Fisher's z-transformed correlation coefficient (ZCOR) -0.45; 95% CI -0.58, -0.32; P less then 0.01] and positively associated with the urine albumin-to-creatinine ratio (UACR; ZCOR 0.26; 95% CI 0.08, 0.43; P less then 0.01), serum creatinine (sCr; ZCOR 0.43; 95% CI 0.28, 0.58; P less then 0.01), urine albumin excretion rate (UAER; ZCOR 0.06; 95% CI 0