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It really is understood that progesterone promotes the proliferation and differentiation of OPC at the beginning of postnatal life through the activation associated with the intracellular progesterone receptor (PR). Progesterone supports neurological myelination after spinal cord injury in adults. Nevertheless, the role of progesterone in embryonic OPC differentiation along with the specific PR isoform taking part in progesterone actions in these cells is unknown. Simply by using primary cultures receiv
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