https://www.selleckchem.com/pr....oducts/dubs-in-1.htm
Using the novel DAP signaling domain construct, the effects of suboptimal CAR signaling were overcome to produce huLym-1-B CAR T cells with improved expansion ex vivo and function in vivo In addition, the Lym-1 epitope does not significantly downregulate in response to huLym-1-B-DAP CAR T cells both ex vivo and in vivo Conclusions DAP intracellular domains can serve as signaling motifs for CAR, and this new construct enables non-impaired production of huLym-1-B CAR T cells with potent in vivo anti-tumor efficacy. Copyright ©2020, Amer
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