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e-use permitted under CC BY. Published by BMJ.Introduction Ebola virus disease (EVD) is one of the deadliest haemorrhagic fevers affecting humans and non-human primates. Thirty-four outbreaks have been reported in Africa since it was first recognised in 1976. This review analysed 42 years of EVD outbreaks and identified various challenges and opportunities for its control and prevention in Sub-Saharan Africa. Methods A literature search of relevant articles on EVD was done in PubMed, Web of Science and Google Scholar electronic databases.