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87 ± 0.9% of oocyte in MII vs 0.81 ± 3.9%; .05) to fertilization, embryo development (57.7% vs 75.7% grade 1 embryo; .05) and reproductive outcomes. Its regular administration both in sub-fertile women and men shows to reduce pelvic pain in endometriosis ( .05), regularize menstrual flow and metabolic disorders ( .01) and improve sperm quality ( .001). ALA represents a promising new molecule in the field of couple infertility. More clinical studies are needed in order to enhance its use in clinical practic