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Good agreement is demonstrated between the experimental data and results of simulation. The influence of volume fraction of nanoparticles, concentration of cross-links, and topology of a polymer network on material parameters is analyzed numerically.Human tooth enamel, the most mineralized tissue in body, contains less than 2 wt% protein. Consequently, the importance of the protein to enamel mechanical response has always been overlooked. In this study, the role of minor protein in providing enamel microstructure and mechanical performa
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