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valuate the clinical utility of these biomarker panels in patients with NAFLD.Chronic liver disease (CLD) causes significant morbidity and mortality in the United States with regional variations. Comparable and consistent state-level measures of CLD-related morbidity and disability among U.S. states have not been well studied. Our aim was to assess the CLD burden within the United States between 2007 and 2017 based on the most common causes of CLD hepatitis B virus, hepatitis C virus (HCV), alcoholic liver disease (ALD), and nonalcoholic