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Incidence of invasive pneumococcal disease (IPD) has been low during the peak of the COVID-19 pandemic. In this study, we found that the IPD numbers again increased in Switzerland during the first six months of 2021, and that this coincides with the loosening of COVID 19 measures.Vaccine pneumococcal serotypes have continued to decrease but non-vaccine type serotype 23B has emerged (8% of the isolates in 2021). Worryingly, serotype 23B is associated with reduced susceptibility to penicillin. This study aimed to quantitatively and objecti