https://www.selleckchem.com/products/shikonin.html
In humans, after adjusting for confounders, the odds of having High_FPG (≥5.6mmol/L) were significantly increased by 25% in the participants in the fourth BLL quartile (OR 1.25, 95% CI 1.05, 1.49). In the animals exposed to 0.05% Pb, FPG, HGP and hepatic gene expression levels of PEPCK, G6PC and FBP1 were increased. In addition, the mRNA expression levels of PEPCK, G6PC and FBP1 in HepG2 cells were also increased in response to Pb exposure. These findings support the possibility that low-level Pb exposure may increase HGP by affecting
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