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Serum sLHCGR decreased markedly during puberty in healthy boys (p = 0.0001). In healthy men, serum sLHCGR was inversely associated with the Inhibin B/FSH ratio (β -0.004, p = 0.027). In infertile men, seminal fluid sLHCGR was inversely associated with serum FSH (β 0.006, p = 0.009), sperm concentration (β -3.5, p = 0.003) and total sperm count (β -3.2, p = 0.007). The injection of hCG lowered sLHCGR in serum and urine of healthy men (p less then 0.01). In conclusion, sLHCGR is released into body-fluids and linked with pubertal developme
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