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48, 95% CI 0.24-0.98,  = 0.045). A trend test found a statistically significant decrease in the proportion of recurrence by including the three favourable factors ( wildtype/low proportion of mutated alleles, low proliferation and high presence of TILs) (  = 0.0004). When at least two out of three factors were present there was a statistically significant association with longer recurrence free survival in the multivariate analysis (HR 0.30, 95% CI 0.15-0.61,  = 0.001) when adjusted for Breslow thickness, an established independent p

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