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. Cerebellar-premotor region connectivity may play a role in the anti-tremor effects of TAPS. Non-invasive peripheral nerve stimulation, also referred to as transcutaneous afferent patterned stimulation (TAPS), reduces hand tremor in essential tremor subjects. Longitudinal TAPS therapy alters cerebellar metabolism, which can be a cause or consequence of tremor reduction. Cerebellar-premotor region connectivity may play a role in the anti-tremor effects of TAPS.Propane (C3H8) and butane (C4H1 are short straight-chain alkane