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INPLASY2020110095 (DOI number 10.37766/inplasy2020.11.0095). INPLASY2020110095 (DOI number 10.37766/inplasy2020.11.0095). Diabetic retinopathy (DR) is a common diabetic microvascular complication, and it is also the main cause of blindness in adults. At present, some studies have reported acupoint injection for the treatment of DR. However, the effectiveness and safety are still uncertain. This study aims to evaluate the efficacy and safety of acupoint injection for the treatment of patients with DR. The databases of English databases (