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Background We previously reported chronic respiratory effects in children who were then 7-17 years of age in Matlab, Bangladesh. One group of children had been exposed to high concentrations of arsenic in drinking water in utero and early childhood (average 436 µg/L), and the other group of children were never known to have been exposed to 10 µg/L. The exposed children, both males and females, had marked increases in chronic respiratory symptoms. Methods The current study involves a further follow-up of these children now 14-26 yea