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ory (r= - 0.43, p = 0.02) among subjects with a CSF AD profile. The novel CSF markers NFL and GFAP show potential as markers for cognitive decline among individuals with core AD pathology at the symptomatic pre- and early stages of dementia. The novel CSF markers NFL and GFAP show potential as markers for cognitive decline among individuals with core AD pathology at the symptomatic pre- and early stages of dementia. HIV-1 produces defective mutants in the process of reproduction. The significance of the mutants has not been well investig