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At sacrifice bone tissue and stem cells were collected for analysis, including μCT and RT-qPCR. Inclusion of PA to your diet had no impact on trabecular bone tissue variables. Nevertheless, marrow adiposity ended up being considerably increased in PA-fed mice, and in bone marrow stromal cells separated from the mice increases into the expression regarding the lipid storage genetics, Plin1 and Cidec, had been seen. Therefore, as a downstream metabolite of kyn, PA no longer revealed kyn's damaging results on bon
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