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Here we explain the introduction of tough liquid syndrome in 30 patients following sequential failure of the reverse osmosis product and liquid softeners. Serum calcium amounts rose from 2.43 ± 0.19 to 3.92 ± 0.51 mmol/L after exposure. All patients required crisis haemodialysis and four acutely deteriorated, certainly one of who was 24 days expecting. This is actually the biggest reported series of customers suffering from this uncommon and serious condition. This event led to the introduction of pr
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