https://www.selleckchem.com/pr....oducts/epacadostat-i
Amide bond formation is one of the most important reactions in biochemistry, notably being of crucial importance for the origin of life. Herein, we combine scanning tunneling microscopy and X-ray photoelectron spectroscopy studies to provide evidence for thermally activated abiotic formation of amide bonds between adsorbed precursors through direct carboxyl-amine coupling under ultrahigh vacuum conditions by means of on-surface synthesis. Complementary insights from temperature-programmed desorption measurements and densi
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