https://www.selleckchem.com/pr....oducts/otub2-in-1.ht
An R-loop is a three-stranded chromatin structure that consists of a displaced single strand of DNA and an RNADNA hybrid duplex, which was thought to be a rare by-product of transcription. However, recent genome-wide data have shown that R-loops are widespread and pervasive in a variety of genomes, and a growing body of experimental evidence indicates that R-loops have both beneficial and harmful effects on an organism. To maximize benefit and avoid harm, organisms have evolved several means by which they tightly regulate R-loop leve