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The effect on the plasma volume was smaller than indicated by these figures because fluid distributed to the extravascular space continuously redistributed to the plasma. Worked-out examples show that one-third of an infused crystalloid volume has been confined to the "third space" after 3 h of surgery. When equilibration with the plasma eventually occurs, which is necessary for excretion of the fluid, is not known. During anesthesia and surgery one third of the infused crystalloid fluid is at least temporarily unavailable for excretio
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