https://www.selleckchem.com/pr....oducts/cbr-470-1.htm
RESULTS On day 5, bone resorption was significantly greater in the trauma group compared with the control group or the trauma + glyburide group, and there were significantly higher numbers of osteoclasts and cells positive for IL-1β, NLRP3, and RANKL in the trauma group. CONCLUSION In this study, glyburide inhibits bone resorption by traumatic occlusion in rats. It suggests that the NLRP3/IL-1β pathway might be associated with bone resorption induced by traumatic occlusion. © 2020 John Wiley Sons A/S. Published by John Wiley &am