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15, = .01). The strength of association of [Formula see text] with mortality was similar to that of V /V and ventilatory ratio. [Formula see text] was independently associated with hospital mortality in subjects with ARDS caused by COVID-19. [Formula see text] could be used at the patient's bedside for outcome prediction and severity stratification, due to the simplicity of its calculation. These findings need to be confirmed in subjects with ARDS without viral pneumonia and when lung-protective mechanical ventilation is not rigorously app
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