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The Science Behind Stubborn Fat Stubborn fat is a term used to describe fat deposits in the body that are resistant to diet and exercise. This type of fat is often found in areas like the abdomen, thighs, and hips. The reason behind the stubbornness of this fat lies in the distribution and function of certain receptors called adrenergic receptors, specifically the alpha-2 adrenergic receptors. These receptors inhibit the breakdown of fat, making it harder to lose wei