https://www.selleckchem.com/pr....oducts/Tretinoin(Abe
These data provide evidence for the first time in a cancer-predisposition gene, that certain presumed null variants can retain function due to their impact on splicing. Further studies are required to estimate cancer-risk associated with these hypomorphic variants. More generally, our findings highlight the need to exercise caution in the interpretation of putative LoF variants susceptible to induce in-frame splicing modifications. Copyright ©2020, American Association for Cancer Research.Worldwide, it is estimated that about