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Treatment success was corroborated by clearance of pleural opacities on radiographs (from median 27.0% [IQR=17.1-44.5] to 11.0% [IQR=6.4-23.3] of hemithorax, p 0.0001), increased pleural fluid drainage (1.98 L [median, IQR=1.38-2.68] over 72 h following commencement of tPA/DNase) and reduction of serum C-reactive protein level (by 45.0% [IQR=39.3-77.0] from baseline at day 5, p 0.0001). Two patients required surgery. Six patients with significant comorbidities (e.g., advanced cancer) had ongoing infection when palliated and die