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This proof concept research would be to determine the effectiveness of sequential treatment with vorinostat and BRAFi/MEKi in resistant BRAFV600E mutant melanoma. The principal aim is showing anti-tumor response of modern lesions based on RECIST 1.1. Additional end points tend to be to find out that rising resistant clones with a secondary mutation when you look at the MAPK path is recognized in circulating cyst DNA and purged by s