https://www.selleckchem.com/pr....oducts/tunicamycin.h
Obesity is a major risk factor for SARS-CoV-2 infection and COVID-19 severity. The underlying basis of this association is likely complex in nature. The host-cell receptor angiotensin converting enzyme 2 (ACE2) and the type II transmembrane serine protease (TMPRSS2) are important for viral cell entry. It is unclear whether obesity alters expression of Ace2 and Tmprss2 in the lower respiratory tract. Here, we show that 1) Ace2 expression is elevated in the lung and trachea of diet-induced obese male mice and reduced in the esophagus
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