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Furthermore, the effect of pioglitazone to control the inflammatory response during IRI progression was examined. Liver metastasis along with MMP-9 activation and the production of inflammatory cytokines were resistant to pioglitazone. Our results indicate that liver metastasis and associated inflammation in mice were resistant to pioglitazone.Two clusters of the coronavirus disease 2019 (COVID-19) were confirmed in Hokkaido, Japan, in February 2020. To identify these clusters, this study employed web search query logs of multiple devices