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The effects of the number of load cases, measurement error, and initial guesses on the results of the inverse problem are investigated, as well. It is observed that the unloaded configuration of the computational breast phantom with a single inclusion or heterogeneous breast tissues can be accurately found by considering an equivalent homogenous material for the tissue.Intranasal administration of drugs serves as a promising, noninvasive option for the treatment of various disorders of the central nervous system and upper respiratory tract