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In recent years, cell-free concentrated ascites reinfusion therapy (CART) has been used to treat patients with malignant ascites. However, CART involves enrichment and reinfusion of useful proteins and inflammatory cytokines. Therefore, fever is a primary side effect and significant problem for patients with ascites. We removed interleukin (IL)-6, an inflammatory cytokine, by mixing malignant ascites and the hexadecyl group adsorbent from a β2-microglobulin-adsorbing column (Lixelle S-15). As a result, the hexadecyl grope adsorbent did