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https://www.selleckchem.com/pr....oducts/lonidamine.ht
RNA sequencing analysis showed that the expression levels of 28 genes related to inflammation were up-regulated ( 2-fold), and six genes were down-regulated ( 0.6-fold) in the control ob/ob mice compared to normal mice. In contrast, the gene expression levels were restored to the normal level by SFN. The protein-protein interaction (PPI) network showed that chemokine ligand (Cxcl14, Ccl1, Ccl3, Ccl4, Ccl17) and chemokine receptor (Ccr3, Cxcr1, Ccr1 were located in close proximity and formed a "functional cluster" in the mid

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