https://www.selleckchem.com/pr....oducts/i-bet151-gsk1
The synthesis of a heteromacrocyclic bifunctional chelator with phosphonic acid pendent arms is presented along copper(ii) complexation. Ligand N2S2-POH featuring N,N'-bis-substituted phosphonate pendent arms was isolated in respectable yields, characterized, and chelated to copper(ii). Implementation of both Moedritzer-Irani and Kabachnik-Fields conditions using aza-thia macrocycle 1,8-dithia-4,11-diazacyclotetradecane afforded 1,8-dithia-4,11-diazacyclotetradecane-4,11-diyl-bis-(methylene)-bis-(phosphonic acid) (N2S2-POH)
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