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The star-like SERS substrate also displays high detection uniformity (with 10-7M Rhodamine 6G) and a low detection limit (down to 10-12M Rhodamine 6G).Objective. To determine factors which influenced the relationship between blood carbon dioxide (pCO2) and end-tidal carbon dioxide (EtCO2) values in ventilated, newborn infants. Furthermore, to assess whether pCO2levels could be predicted from continuous EtCO2monitoring.Approach. An observational study of routinely monitored newborn infants requiring mechanical ventilation in the first 2