https://www.selleckchem.com/
Abnormal overexpression of tyrosinase activity can lead to the production of hyperpigmentation in human skin and enzymatic browning in fruits and vegetables. Herein, the inhibition and mechanism of the H3 PMo12 O40 and two transition metal-substituted Keggin-type polyoxometalates (Na7 PMo11 CoO40 and Na7 PMo11 ZnO40 ) on tyrosinase were studied by kinetics and molecular modeling. Kinetic studies indicated that all compounds had more potent inhibitory activities than standard arbutin, and H3 PMo12 O40 (IC50 = 0.443 ± 0.006 mM) is approximately 15-fold strong