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OBJECTIVE Hence, we have performed this research to look for the safety and efficacy of sofosbuvir combination treatment in this hard to treat populace. METHODS We conducted a single-center, prospective, open-label research in which Stage 5 CKD clients on maintenance hemodialysis with HCV infection. Total of 18 patients had been included. sofosbuvir with daclatasvir or ledipasvir was made use of according to genotype for 12 days. HCV RNA, genotype, transient ela