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Diet and lifestyle may affect risk for metabolic-associated fatty liver disease (MAFLD) by chronically elevating systemic inflammation. In this study we investigated the separate and joint associations of dietary and lifestyle inflammation scores (DIS and LIS, respectively) with MAFLD risk. For this nested case-control study we identified and recruited 968 patients with MAFLD (defined as having a fatty liver index≥60 plus ≥1 of the following conditions overweight or obese, type II diabetes mellitus, evidence of metabolic dysregulation)