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Publication bias was assessed by the construction of funnel plots. RESULTS Eleven studies met the inclusion criteria. Meta-analysis showed that coating of titanium surfaces with bisphosphonates increases alkaline phosphatase activity in osteoblasts after 3 days (n = 1), 7 (n = 7), 14 (n = 6) and 21 (n = 3) days. (7 days beta coefficient = 1.363, p-value = 0.001; 14 days beta coefficient = 1.325, p-value less then  0.001; 21 days beta coefficient = 1.152, p-value = 0.159). CONCLUSIONS The meta-analysis suggests that bisphosphonate coatin