https://www.selleckchem.com/pr....oducts/sar131675.htm
Synaptic damage is a key pathology of Alzheimer's disease (AD). The mechanism underlying synaptic vulnerability in AD remains elusive. Using a large-scale transcriptomic dataset, we analyzed the neurogranin-centered integrative gene network and assessed the correlation of neurogranin ( ) gene expression with AD pathology in brains. We studied the association of expression with Clinical Dementia Rating (CDR) and neuropathological diagnosis of AD. We find that the genes positively correlated with expression in AD are involved in synapti