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In low-middle and low socio-demographic index regions, the decreasing trends were slower than other regions with an average annual percentage change of -2.1% (95% CI -2.2 to -2. and -2.1% (95% CI -2.1 to -2., respectively. Among six geographical regions, Africa presented the highest age-standardized DALY rates of 352 (95% CI 275-41 per 100,000 in 1990 and 208 (95% CI 175-236) per 100,000 in 2017, and also the slowest average decreasing trend, with an average annual percentage change of -1.9% (95% CI -2 to -1.8). The global burden
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